- FROM THE NORTH (Asheville, NC) Follow I-26 E. Enter South Carolina on US 25 South toward US 276 S
- FROM THE SOUTH (Columbia, SC) Follow I-26 W to I-385 N to Greenville
- FROM THE EAST (Charlotte, NC) Follow I-85 South to I-385 N to Greenville
- FROM THE WEST (Atlanta, GA) Enter South Carolina on Interstate 85 N. Merge to I-186N/US 29N to Greenville
